Speakers
Hot Topics: Rehab/Neural Engineering
This panel explores the hot topics of rehabilitation and neural engineering. What are the current technologies? What are some of the challenges in these areas and what kinds of technologies will the future bring?* Moderator: David Mogul, Ph. D., Chair, Department of Biomedical Engineering, Illinois Institute of Technology
Dr. Mogul received his B.S. degree in Electrical Engineering at Cornell University and his M.S. and Ph.D. degrees, also in Electrical Engineering, at Northwestern University. He then performed a postdoctoral fellowship at the University of Chicago in the Department of Pharmacological & Physiological Sciences. Following his fellowship, he joined the faculty of the Department of Biomedical Engineering at Northwestern University in 1992. In 1999, he joined ZS Associates, an international consulting firm where he consulted primarily with companies in the pharmaceutical and medical device industries. Dr. Mogul joined the Illinois Institute of Technology in 2002 where he is currently Associate Professor and Interim Chairman of Biomedical Engineering.
Dr. Mogul’s research can be summarized as the study of the electrophysiology and electrical dynamics of the brain. His laboratory has applied a quantitative and neuroengineering approach toward understanding and modulating brain physiology using both conventional and novel experimental techniques in several related areas. One major research area in his laboratory is in applying deep brain stimulation to combat epilepsy. Epilepsy is the most common neurological disease, yet a significant fraction of these patients cannot be sufficiently helped with currently available anti-epileptic drugs. The ultimate objective of this research is to engineer a less invasive and potentially far less damaging alternative to surgery for drug-refractory epilepsy patients. The overall goal is to engineer a device similar in concept to an implantable cardiac defibrillator in that it would detect the earliest stages of a seizure and prevent or revert it using electrical stimulation. This research requires exploration in diverse but related fields such as nonlinear dynamical analysis and feedback control theory as well as expertise in experimental biology. A second major area of research is in the use of Transcranial Magnetic Stimulation (TMS) for modulating brain activity. TMS is a technique that permits non-invasive activation of select areas of the brain using dynamic magnetic fields. Use of TMS in a clinical setting has already been reported for a number of applications including the treatment of intractable depression and assessment and treatment of motor cortical function following stroke. Because TMS can both excite and inhibit brain activity depending on stimulation protocols, it has the potential to be a very powerful research tool as well. However, many technical issues regarding this technique remain. The pioneering research in his laboratory applies computational electromagnetics, neuroimaging, and advanced dynamical analysis in order to better understand and improve the technique of transcranial magnetic stimulation providing new and more precise ways of modulating brain activity non-invasively. Dr. Mogul has received funding from the NIH, the NSF, and private foundations for his laboratory’s various research projects.
Dwight Nelson, Ph. D., Research Manager, Neuromodulation Research, Medtronic
Dwight obtained his PhD from the Department of Neurobiology
and Physiology at Northwestern University (IL) and completed
post-doctoral experiences at the University of Virginia and Abbott
Laboratories Pharmaceutical Products Division. His graduate and
postdoctoral research focused on basic research into visual
pathways that mediate entrainment of mammalian circadian pacemakers. At Abbott Dwight was a member of a pharma venture group and planned and conducted phase I / II clinical trials for a first-in-class renin inhibitor with a focus on 24h monitoring and control of cardiovascular
function.
Following his post-docs, Dwight retuned to an academic position as research / teaching faculty at the University of St. Thomas in St. Paul, MN. While there Dwight’s research interests focused on genetic and photic control of mammalian circadian systems, the influence of genetic knockouts and mutations on the function and entrainment of pacemakers and in vitro assays of mammalian circadian and photoperiodic function. With funding support from both NSF and NIH, Dwight has authored over 18 published articles and 24 abstracts and presented over 50 additional abstracts and research talks relating to his work.
In the 1990’s Dwight began work as a collaborator with Medtronic Neuromodulation on hypothalamic neurostimulation projects. On a sabbatic leave from his academic position in 2000-2001 Dwight worked with Medtronic on early stage research projects. Since joining Medtronic Neuromodulation full time in 2008, Dwight has worked in Neurostimulation Research group with a focus on neural control of peripheral organs and physiology as well as deep brain stimulation projects. Dwight leads both the Peripheral and Autonomic Neuromodulation Research team as well as the DBS for Movement Disorders research team.
Eric Perreault, PhD, Rehabilitation Institute of Chicago
Eric Perreault is an Associate Professor at Northwestern University, with appointments in the Department of Biomedical Engineering and the Department of Physical Medicine and Rehabilitation. He also is a member of the Sensory Motor Performance Program at the Rehabilitation Institute of Chicago, where his laboratory is located.
Eric received his B.Eng and M. Eng degrees in Electrical Engineering from McGill University in 1989 and 1991, respectively. After working in industry for 4 years, Eric enrolled in the Biomedical Engineering Department at Case Western Reserve University, completing his PhD in 2000. From 2000-2002, he was a postdoctoral fellow in the Department of Physiology at Northwestern University. In 2010, he was a Visiting Professor at ETH Zürich.
Eric’s current research focuses on understanding the neural and biomechanical factors involved in the control of multi-joint movement and posture and how these factors are modified following neuromotor pathologies such as stroke and spinal cord injury. The goal of his research is to provide a scientific basis for understanding normal and pathological motor control that can be used to guide rehabilitative strategies and user interface development for restoring function to individuals with motor deficits. Current applications include rehabilitation following stroke and tendon transfer surgeries, and user interfaces for neuroprosthetic control.
Currently, Eric serves is an Associate for the IEEE Transactions on Neural Systems and Rehabilitation Engineering, and serves on the editorial boards for the Journal of Motor Behavior and the Journal of Motor Control. He also is a member of the IEEE Technical Committee on Rehabilitation Robotics.
James Hickman, Ph.D., Professor, University of Central Florida
James J. Hickman is the Founding Director of the NanoScience Technology Center and a Professor of Nanoscience Technology, Chemistry, Biomolecular Science, Physics and Electrical Engineering at the University of Central Florida. Previously, he held the position of the Hunter Endowed Chair in the Bioengineering Department at Clemson University. Dr. Hickman has a Ph.D. from the Massachusetts Institute of Technology in Chemistry, as well as BS and MS from Penn State University in Chemistry. His Ph.D. thesis research involved the modification and characterization of microelectrodes and MEMS devices derivatized with self-assembled monolayers. For the past twenty years, he has been studying the interaction of biological species with modified surfaces, first in industry and in the latter years in academia. While in industry he established one of the first bioelectronics labs in the country that focused on cell-based sensors and their integration with electronic devices. He has extensive experience in surface modification and surface analysis for biological and neuroscience applications, and the integration of these systems with MEMS devices and components. He is also interested in creating hybrid systems for biosensor and biological computation applications and the creation of functional in vitro systems. He has worked at the NSF part-time as a special advisor to the Experimental and Integrative Activities Division in CISE in the area of biological computation and previously had worked with the Information Technology Office at DARPA to help develop new programs in Ultrascale computing. He is also the founder and current CTO of a biotechnology company, Hesperos, that is focusing on cell-based systems for high-throughput functional genomics and toxicity. He has 81 publications and 16 book chapters, in addition to 16 patents. He has presented over 80 invited presentations with more than 100 total presentations. Dr. Hickman was elected a Fellow of the American Institute of Medical and Biomedical Engineers in 2004 (AIMBE) and a fellow of the AVS in 2007 and is currently a member of the Board of Directors for AIMBE. He was a founding member of the Biomaterial Interfaces Technical Group for the American Vacuum Society, and Chair from 1995-2000. He received the NSF Director’s Award for Collaborative Integration for contributions to integrating biology and information technology research in 2002. He received the SAIC Publication Award in 1993, 1994 and 1995; the Berman Award from the NRL in 1993 and 1995; the SAIC Technology Achievement Award in 1995 and the MIT Gold Award for community service in 1989.
John Hetling, Associate Professor, Department of Bioengineering, University of Illinois at Chicago
John R. Hetling has been on the faculty in the Department of Bioengineering at UIC for 13 years, with an adjunct appointment in the Department of Ophthalmology and Visual Sciences. He earned his B.S. in Biology from Bates College in 1989, and studied central pattern generators for two years before entering the PhD program in Bioengineering at UIC, graduating in 1997. John is a neural engineer, with emphasis on developing tools and techniques related to vision science and ophthalmic care. He is heavily involved in bioengineering education; he has served as Director of Undergraduate Studies for 9 years, and was awarded an NSF Course, Curriculum and Laboratory Improvement grant in 2001 to develop a laboratory course in Neural Engineering. He has been honored with several teaching awards.
John’s research program has focused on hybrid neural systems, with the broad goal of optimizing the flow of information between living and non-living components, for basic research or clinical applications. Research projects have included the study of electrode-retina interfaces for vision prostheses, hybrid-device olfactory biosensors, electrical stimulation therapy for degenerative eye disease, and electrophysiological functional imaging in the eye. He currently directs the Neural Engineering Vision Laboratory (NEVL) at UIC, and collaborates with multiple clinical centers to evaluate efficacy of novel diagnostic technologies. John has received research support from The Whitaker Foundation, Department of Veterans Affairs, DARPA, NSF, NIH, private foundations and industry.
John has been increasingly involved in translational research; in 2009 he and colleagues founded RetMap, Inc. to foster commercialization of products related to diagnosis of progressive eye disease. RetMap was awarded an Innovation Challenge Technical Assistance Grant in 2010, and was the first UIC-based startup to participate in the Chicago Innovation Mentors program. To better prepare bioengineers for leading roles in translational science, he has worked to add courses in medical product development to the UIC BioE curriculum.